Eur J Endocrinol
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DOI: 10.1530/EJE-07-0370
European Journal of Endocrinology, Vol 157, suppl_1, S1
Copyright © 2007 by European Society of Endocrinology
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ARTICLE

The evolving biology of growth and metabolism

Stefano Cianfarani, Yves Le Bouc and Martin Savage

E-mail: m.o.savage{at}qmul.ac.uk

This supplement comprises the proceedings of an outstanding symposium organised and funded by Ipsen in Lisbon in March 2007.

The aim of the symposium was to highlight and discuss major clinical and scientific advances in the fields of linear growth and related metabolism. The supplement includes reviews on the genetic defects of hypothalamo–pituitary development affecting growth hormone (GH) secretion and of the GH–insulin-like growth factor-I (IGF-I) axis affecting GH and IGF-I action. Genotype–phenotype relationships are discussed in detail. The topic of fat distribution and its influence on glucose metabolism and insulin resistance is covered, together with an exposé on the treatment of insulin resistance syndromes using recombinant human IGF-I.

Therapeutic aspects of growth disorders are also described in articles on rhIGF-I therapy in GH resistance and the emergence of pharmacogenomics as a genetic adjunct to the management of patients with short stature. The predictive value of genotyping to the choice of growth-promoting therapy is also discussed. Metabolic implications of GH therapy in children born small for gestational age are also discussed. The proceedings also contains a very interesting report of adrenal failure in a child with phytosterolaemia, and a report of a new GH mutant in a pedigree presenting with growth and pubertal development.

The articles in this supplement achieve a balance between the presentation of molecular advances and clinical aspects of management directly related to the care of the child with abnormal linear growth.





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