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THE EFFECT OF DIPHENYLHYDANTOIN IN VITRO ON THE FORMATION OF THE POLAR METABOLITES OF TESTOSTERONE BY RAT LIVER

Significant inhibition of the conversion of testosterone to polar hydroxylated derivatives can be produced in rat liver slice incubations if large enough amounts of diphenylhydantoin are added. The amount needed to produce this effect is greater in male than in female incubates. The latter under control conditions convert a greater percentage of testosterone to polar metabolites but this difference is eliminated by the addition of diphenylhydantoin at each of the three concentrations utilized in this study.

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