Eur J Endocrinol
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DOI: 10.1530/acta.0.0560490
Acta Endocrinologica, Vol 56, Issue 3, 490-498
Copyright © 1967 by European Society of Endocrinology
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THE EFFECT OF DIPHENYLHYDANTOIN IN VITRO ON THE METABOLISM OF TESTOSTERONE BY RAT LIVER SLICES

Leon J. Sholiton, Emile E. Werk and Joseph MacGee

The metabolism of testosterone-4-14C by rat liver slices has been evaluated with and without the presence of diphenylhydantoin (DPH). Radioactive metabolites were identified by paper chromatography and recrystallization to constant specific activities with appropriate standards. With female rat liver slice incubation, under the conditions utilized, androsterone (A) and allo-tetrahydrotestosterone (allo-THT) is increased 4–5 fold by the presence of DPH. In the male, aetiocholanolone (E) and tetrahydrotestosterone (THT) formation is noted with increased conversion to these in the presence of DPH. It is postulated that the DPH effect may be due to competitive inhibition of hepatic microsomal hydroxylase activity while allowing for unabated {Delta}4-reductase action.




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