Eur J Endocrinol
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DOI: 10.1530/EJE-08-1014
European Journal of Endocrinology, Vol 161, Issue 2, 317-322
Copyright © 2009 by European Society of Endocrinology
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CLINICAL STUDY

Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor {gamma}2 with decreased basic metabolic rate in women with polycystic ovary syndrome

Vasiliki Koika1,2, Dimitra J Marioli1,2, Alexandros D Saltamavros1,2, Vasiliki Vervita1,2, Kleanthis D Koufogiannis2, George Adonakis1,2, George Decavalas2 and Neoklis A Georgopoulos1,2

1 , Division of Reproductive Endocrinology2 Department of Obstetrics and Gynecology, University of Patras Medical School, University Hospital, 26500 Patras, Greece

(Correspondence should be addressed to N A Georgopoulos; Email: neoklisg{at}hol.gr)

Objective: The peroxisome proliferator-activated receptor (PPAR){gamma} is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPAR{gamma}2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic ovary syndrome (PCOS). We have recently shown a decreased basic metabolic rate (BMR) in PCOS. The aim of the present study is to determine the prevalence of the Pro12Ala polymorphism of the PPAR{gamma}2 gene and its associations with indices of IR and BMR in lean and slightly overweight PCOS women.

Design: Case–control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls.

Methods: Hormonal determinations were performed by electrochemiluminescence quantitation or RIA. BMR was measured by indirect calorimetry. All subjects were genotyped by a PCR–restriction fragment length polymorphism assay.

Results: Genotype frequencies of the Pro12Ala polymorphism in PPAR{gamma}2 did not differ among PCOS women and control subjects.

The presence of Pro12Ala polymorphism of PPAR{gamma}2 was associated with lower BMR (P=0.04). This finding was valid in our subgroup of lean PCOS (BMI<25 kg/m2), in which the Ala variant was also associated with higher total testosterone values.

Conclusion: The Pro12Ala polymorphism in the PPAR{gamma}2 gene is associated with decreased BMR in women with PCOS and biochemical hyperandrogenemia. These young women are therefore at risk to increase their body weight and should restrict their energy intake by diet and enhance their energy expenditure by exercise.






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