HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: EJE-08-0707v1 160/4/647    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sereg, M. Articles by Tóth, M. Search for Related Content PubMed PubMed Citation Articles by Sereg, M. Articles by Tóth, M.

Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study

Márta Sereg¹, Ágnes Szappanos¹, Judit Tke¹, Kinga Karlinger², Karolina Feldman¹, Éva Kaszper¹, Ibolya Varga^1,3, Edit Gláz¹, Károly Rácz¹ and Miklós Tóth¹

¹ 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi u. 46, Budapest H-1088, Hungary² Department of Diagnostic Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary³ Molecular Medicine Research Group, Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary

(Correspondence should be addressed to M Tóth; Email: totmik{at}bel2.sote.hu)

Objective: Despite the increased prevalences of hypertension, type 2 diabetes mellitus (T2DM), hyperlipidemy, and obesity in patients with non-functioning adrenal adenomas (NFAAs), there is a paucity of data on long-term atherosclerotic morbidity as well as the long-term cardiovascular effects of adrenalectomy in these patients.

Design, patients, and methods: This retrospective study includes the results of baseline and follow-up investigations of 125 patients (29 males and 96 females; mean age 60.1 years) with NFAAs referred for endocrine evaluation between 1990 and 2001. Of the 125 patients, 47 underwent unilateral adrenalectomy, while 78 patients were followed conservatively. These patients were reinvestigated after a mean follow-up time of 9.1 (5–16) years in 2006, with special emphasis on laboratory and other atherosclerotic risk factors (ARF), vascular events, and interventions.

Results: The prevalences of hypertension, impaired glucose tolerance or T2DM, hyperlipidemy, and obesity were 82, 43, 58, and 50%, and 89, 58, 82, and 50% at baseline and follow-up, respectively. None of the investigated ARF prevalences were different between patients treated and not treated with adrenalectomy, and between patients with and without subclinical Cushing's syndrome. The prevalences of angina pectoris, acute myocardial infarction, coronary, and peripheral arterial interventions or cerebrovascular stroke did not differ significantly between patients treated and not treated with adrenalectomy.

Conclusion: Our study confirms previous investigations reporting markedly increased prevalences of various ARF in patients with NFAAs. Adrenalectomy performed in these patients failed to decrease the prevalence of ARF and atherosclerotic morbidity.

This article has been cited by other articles:

				C. Eller-Vainicher, V. Morelli, A. S. Salcuni, M. Torlontano, F. Coletti, L. Iorio, A. Cuttitta, A. Ambrosio, L. Vicentini, V. Carnevale, et al. Post-surgical hypocortisolism after removal of an adrenal incidentaloma: is it predictable by an accurate endocrinological work-up before surgery? Eur. J. Endocrinol., January 1, 2010; 162(1): 91 - 99. [Abstract] [Full Text] [PDF]