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DOI: 10.1530/EJE-08-0689
European Journal of Endocrinology, Vol 160, Issue 3, 465-468
Copyright © 2009 by European Society of Endocrinology
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CLINICAL STUDY

Quality of life is reduced in patients with Klinefelter syndrome on androgen replacement therapy

Willem de Ronde, Anne de Haan and Madeleine L Drent

Department of Endocrinology, Vrije Universiteit Medical Center, 1081 HV Amsterdam, The Netherlands

(Correspondence should be addressed to W. de Ronde; Email: p.deronde{at}vumc.nl)

Context: Klinefelter syndrome (KS) is a genetic disorder, characterized by an XXY karyotype, hypergonadotrophic hypogonadism and infertility, which affects ~1 in 700 men. KS has also been associated with neuropsychological alterations.

Objective: To investigate whether quality of life (QoL) is reduced in patients with KS on androgen treatment.

Design: Observational study.

Methods: Questionnaires (RAND-36) were sent to 46 KS patients on androgen treatment who regularly visit the outpatient clinic of an academic medical centre. QoL scores were compared with a Dutch male reference group.

Results: Forty (87%) questionnaires were returned which were suitable for evaluation. KS patients had significantly lower (worse) scores on eight of the nine domains of the RAND questionnaire compared with the male reference group. In KS patients, higher education was associated with significantly better QoL scores.

Conclusions: QoL is reduced in patients with KS on androgen treatment.




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A.-M. B. Bjorn, A. Bojesen, C. H. Gravholt, and P. Laurberg
Hypothyroidism Secondary to Hypothalamic-Pituitary Dysfunction May Be Part of the Phenotype in Klinefelter Syndrome: A Case-Control Study
J. Clin. Endocrinol. Metab., July 1, 2009; 94(7): 2478 - 2481.
[Abstract] [Full Text] [PDF]


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