Eur J Endocrinol
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DOI: 10.1530/EJE-08-0569
European Journal of Endocrinology, Vol 160, Issue 2, 289-293
Copyright © 2009 by European Society of Endocrinology
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CLINICAL STUDY

Adiponectin is associated with low bone mineral density in elderly men

Lourdes Basurto1, Rosa Galván1, Nydia Cordova1, Renata Saucedo1, Columba Vargas2, Sandra Campos1, Elizabeth Halley2, Francisco Avelar2 and Arturo Zárate1

1 , Endocrine Research Unit2 Department of Radiology, National Medical Center, Instituto Mexicano del Seguro Social, Cuauhtémoc 06720 Mexico

(Correspondence should be addressed to L Basurto; Email: lbasurtoa{at}yahoo.com)

Objective: Recent evidence suggests that adiponectin may play a role in bone metabolism. Previous studies demonstrated that the adiponectin levels had a negative correlation with bone mineral density (BMD) in women. However, little is known about the relationship between adiponectin and BMD in men. The aim of this study was to determinate the relationship between the adiponectin levels and BMD in elderly men.

Design: Cross-sectional study including 92 healthy men aged 60–80 years.

Methods: Main outcome measures were the adiponectin levels estimated by RIA and BMD at lumbar spine and femoral neck using dual energy X-ray absorptiometry.

Results: The negative correlation between adiponectin and BMD at the spine was r=–0.209, (P<0.05) and at the femoral neck was r=–0.237, (P<0.001). These correlations disappeared after adjustment for body mass index (BMI). When stratified by BMI, the relationship between BMD and adiponectin remained significant in the subgroup of participants with BMI >27 kg/m2, but disappeared in men with BMI ≤27 kg/m2. In multiple regression analysis, adiponectin was a significant determinant of BMD at the spine, not at the femoral neck, in those with BMI >27.

Conclusion: BMD is negatively associated with the adiponectin levels in men older than 60 years and this relationship is greater in those men with BMI >27, which suggests a plausible connection between bone and fat tissue.






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