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Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and vertebral fractures in type 2 diabetes mellitus

Department of Internal Medicine 1, Shimane University School of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan

(Correspondence should be addressed to T Yamaguchi; Email: yamaguch{at}med.shimane-u.ac.jp)

Background: Although, adiponectin might be associated with bone metabolism, the relationships between serum adiponectin and bone mineral density (BMD) as well as vertebral fracture in type 2 diabetes are still unclear.

Objective and methods: We investigated the relationships between each of serum total and high molecular weight (HMW) adiponectin versus BMD, bone markers, and the presence of vertebral fractures in a total of 231 men and 170 post-menopausal women with type 2 diabetes.

Results: Multiple regression analysis adjusted for age, duration of diabetes, BMI, serum creatinine, and HbA_1c showed that serum total adiponectin was negatively correlated with BMD at the total, lumbar spine, and femoral neck (r=–0.165, P<0.05; r=–0.187, P<0.05; and r=–0.136, P<0.05 respectively) and positively with urinary N-terminal cross-linked telopeptide of type-I collagen in men (r=0.148, P<0.05), and that serum HMW adiponectin was negatively correlated with BMD at the lumbar spine (r=–0.146, P<0.05). Multivariate logistic regression analysis adjusted for the parameters described above showed that total adiponectin was associated with the presence of vertebral fractures in men (odds ratio (OR)=1.396, 95% confidential interval (CI) 1.020–1.911 per S.D. increase, P<0.05), and both total and HMW adiponectin were associated with moderate or severe vertebral fractures (OR=1.709, 95% CI 1.048–2.787 per S.D. increase, P<0.05 and OR=1.810, 95% CI 1.112–2.946 per S.D. increase, P<0.05 respectively), but not in post-menopausal women.

Conclusions: Serum adiponectin could be associated with BMD and turnover and clinically useful for assessing the risk of vertebral fractures in type 2 diabetic men.

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				I. Kanazawa, T. Yamaguchi, M. Yamauchi, M. Yamamoto, S. Kurioka, S. Yano, and T. Sugimoto Adiponectin Is Associated with Changes in Bone Markers during Glycemic Control in Type 2 Diabetes Mellitus J. Clin. Endocrinol. Metab., August 1, 2009; 94(8): 3031 - 3037. [Abstract] [Full Text] [PDF]