Eur J Endocrinol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

DOI: 10.1530/EJE-08-0212
European Journal of Endocrinology, Vol 159, Issue 1, 1-4
Copyright © 2008 by European Society of Endocrinology
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
EJE-08-0212v1
159/1/R1    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Soriano-Guillén, L.
Right arrow Articles by Rovira, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soriano-Guillén, L.
Right arrow Articles by Rovira, A.
RAPID COMMUNICATION

High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

Leandro Soriano-Guillén1,2, Bárbara Hernández-García1, Jimena Pita2, Nieves Domínguez-Garrido1, Genoveva Del Río-Camacho1 and Adela Rovira2,3

1 Deparment of Pediatrics, Fundación Jimenez Diaz, University Autonoma of Madrid, Avenida Reyes Catolicos no 2, 28040 Madrid, Spain2 Laboratory of Endocrinology and 3 Deparment of Endocrinology. Fundacion Jimenez Diaz. University Autonoma of Madrid,, Madrid, Spain

(Correspondence should be addressed to L Soriano-Guillén; Email: lsoriano{at}fjd.es) (leansor4{at}hotmail.com)

Objective: We intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents.

Methods: The study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism.

Results: Out of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8–4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5–2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels.

Conclusion: The hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 European Society of Endocrinology.