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Associations of age-dependent IGF-I SDS with cardiovascular diseases and risk conditions: cross-sectional study in 6773 primary care patients

¹ Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, 01187, Dresden, Germany² Internal Medicine/Endocrinology and Clinical Chemistry, Max Planck Institute of Psychiatry, 80804, Munich, Germany³ Pfizer Ltd, EBT Endocrine Care, Walton Oaks, KT207NS, UK⁴ Pfizer GmbH, 76139, Karlsruhe, Germany⁵ Institute of Clinical Pharmacology, Technical University of Dresden, 01187, Dresden, Germany⁶ Institute of Clinical Chemistry, Medical University Graz, 8036, Graz, Austria⁷ Department of Cardiology/Nephrology, Johann Wolfgang Goethe University, 60590, Frankfurt, Germany⁸ Cardiology Practice and Hospital, 80331, Munich, Germany⁹ Warwick Medical School, University Hospital of Coventry, Coventry, CV220X, UK and ¹⁰ 1st Medical Department, University of Lüebeck, 23538, Lüebeck, Germany

(Correspondence should be addressed to H J Schneider; Email: schneider{at}mpipsykl.mpg.de)

Objective: We aimed at investigating the association of age-dependent IGF-I SDS with diabetes, dyslipidemia, hypertension, and heart diseases, in a large patient sample.

Background: IGF-I has been suggested to be associated with several diseases and a prognostic marker for the development of cardiovascular diseases and risk factors. The findings, though, have been inconsistent possibly due to the methodological factors.

Methods: We studied 6773 consecutive primary care patients, aged 18+ years, in a cross-sectional, epidemiological study in primary care, Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment study. All patients underwent a standardized clinical diagnostic and laboratory assessment. IGF-I levels were measured with an automated chemiluminescence assay system. We calculated the odds ratios (OR) for diseases in quintiles of IGF-I, and additionally analyzed the association of age-dependent IGF-I SDS with these conditions.

Results: After multiple adjustments for confounders, we found increased ORs for coronary artery disease in patients with high IGF-I. Women, but not men, with low IGF-I also showed increased ORs for coronary artery disease. Dyslipidemia was positively associated with IGF-I. Type 2 diabetes showed a curvilinear association with IGF-I SDS.

Conclusions: The findings suggest the existence of multiple and complex interactions between IGF-I and several health conditions. The complex nature of disease- and subgroup-specific associations along with the methodological factors can be held responsible for divergent findings in previous studies.

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