Eur J Endocrinol
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DOI: 10.1530/EJE-07-0318
European Journal of Endocrinology, Vol 157, Issue 4, 515-520
Copyright © 2007 by European Society of Endocrinology
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Thyroid hormone is a critical determinant of myocardial performance in patients with heart failure: potential therapeutic implications

Constantinos Pantos, Athanasios Dritsas1, Iordanis Mourouzis, Antonios Dimopoulos, Georgios Karatasakis1, Georgios Athanassopoulos1, Sofia Mavrogeni1, Athanasios Manginas1 and Dennis V Cokkinos1

Department of Pharmacology, University of Athens, 75 Mikras Asias Avenue, 11527 Goudi, Athens, Greece and 1 1st Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Kallithea, Athens, Greece

(Correspondence should be addressed to C Pantos; Email: cpantos{at}cc.uoa.gr)

Objective: Previous experimental studies have provided evidence showing that changes in thyroid hormone signaling correspond to alterations in myocardial function in animal models of heart failure. The present study further explores whether thyroid hormone alterations are correlated with the functional status of the myocardium in patients with heart failure.

Methods: In this study, 37 patients with mean ejection fraction (EF%) of 26.2 (8.2) were included. Myocardial performance was assessed by echocardiography and cardiopulmonary exercise testing. Total tri-iodothyronine (T3), thyroxine, and TSH levels were measured in plasma.

Results: Total T3 was strongly correlated with VO2max (r = 0.78, P = 2 x 10–8). Furthermore, multivariate analysis revealed that total T3 was an independent predictor of VO2max (P = 0.000 005). A weaker but significant correlation was also found between total T3 and EF% (r = 0.56, P = 0.0004), systolic (r = 0.43, P = 0.009) and diastolic (r = 0.46, P = 0.004) blood pressure.

Conclusions: changes in thyroid hormone were closely correlated to myocardial functional status in patients with heart failure. These data probably indicate a possible role of thyroid hormone in the pathophysiology of heart failure and confirm previous experimental reports.






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