Eur J Endocrinol
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DOI: 10.1530/EJE-07-0459
European Journal of Endocrinology, Vol 157, Issue 4, 473-479
Copyright © 2007 by European Society of Endocrinology
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Regional fat distribution in adolescents with anorexia nervosa: effect of duration of malnutrition and weight recovery

María Teresa García De Álvaro1, María Teresa Muñoz-Calvo1,2, Vicente Barrios1,2, Guillermo Martínez3, Gabriel Ángel Martos-Moreno1,2, Federico Hawkins3 and Jesús Argente1,2

1 Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Avda. Menéndez Pelayo, 65, E-28009 Madrid, Spain,2 Ciber Fisiopatología Obesidad y Nutrición (CB06/03) Instituto de Salud Carlos III, E-28009 Madrid, Spain and3 Department of Endocrinology, Hospital Universitario 12 de Octubre and Universidad Complutense, E-28041 Madrid, Spain

(Correspondence should be addressed to J Argente; Email: argentefen{at}terra.es)

Objective: This study addresses the influence of the duration of malnutrition and the effect of weight recovery on regional fat mass distribution in moderately malnourished adolescents with anorexia nervosa (AN).

Study design: We measured total and regional fat mass and leptin levels in 42 restrictive AN female adolescents and 23 controls. AN patients, followed over 2 years, were divided into three groups: prolonged moderate malnutrition (PM; secondary amenorrhea for over 1 year, n = 14); SM, short period of moderate malnutrition (secondary amenorrhea for less than 1 year, n = 13); and R, recovered from AN (BMI, body mass index and menses recovered for over 6 months, n = 15).

Results: Total, trunk, and extremity fat mass were reduced in the PM and SM groups (P < 0.05), whereas only PM patients showed altered regional fat distribution with a low trunk to extremity fat ratio (P < 0.05). BMI increased after 12 months only in the SM group (P < 0.05), with menses resumption in 69% of these patients and BMI normalization at 24 months. Their regional fat distribution was similar to controls throughout the study. No difference in any parameter was found between the R group and the controls.

Conclusion: Prolonged malnutrition, but not weight recovery, is associated with an abnormal regional fat distribution pattern in moderately malnourished AN adolescents.






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