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DOI: 10.1530/EJE-07-0143
European Journal of Endocrinology, Vol 157, Issue 2, 201-207
Copyright © 2007 by European Society of Endocrinology
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CLINICAL STUDY

Retinol-binding protein 4 levels are elevated in polycystic ovary syndrome women with obesity and impaired glucose metabolism

Susanne Hahn, Manuel Backhaus1, Martina Broecker-Preuss1,2, Susanne Tan1, Tiina Dietz1, Rainer Kimmig3, Markus Schmidt3, Klaus Mann1 and Onno E Janssen4

Endokrinologikum Ruhr, Center for Endocrine and Metabolic Diseases, Alter Markt 4, 44866 Bochum, Germany, 1 Division of Endocrinology, Department of Medicine, 2 Division of Clinical Chemistry and Laboratory Medicine and 3 Department of Obstetrics and Gynecology, University Hospital of Essen Medical School, 45122 Essen, Germany and 4 Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, 60611 Chicago, Illinois, USA

(Correspondence should be addressed to S Hahn; Email: mail{at}susannehahn.com)

Objective: Insulin resistance and obesity are common features of the polycystic ovary syndrome (PCOS). Retinol-binding protein 4 (RBP4), a new fat-derived adipokine, has been described to be elevated in obesity and type 2 diabetes. The aim of the present study was to investigate whether serum RBP4 levels are correlated with metabolic parameters, indices of insulin resistance, and endocrine variables in German PCOS women.

Design: We assessed the correlation between metabolic and endocrine parameters with RBP4 levels in 200 PCOS patients and 64 healthy controls.

Methods: Serum RBP4 was measured by enzyme-linked immunosorbent assay (Immundiagnostik AG, Bensheim, Germany). In addition, anthropometric variables, clinical signs of hyperandrogenism, and body fat were evaluated, and a glucose tolerance test was performed to assess parameters of insulin resistance and glucose metabolism.

Results: Taking the entire PCOS cohort, RBP4 levels were positively correlated with body mass index (BMI), body fat, waist circumference, fasting glucose, and area under the curve for glucose (all P<0.05), but not with indices of insulin resistance. On the other hand, PCOS women with impaired glucose metabolism had higher RBP4 levels than PCOS women with normal glucose metabolism (median 30.6, range 23.3–73.9 versus median 26.3, range 6.4–61.4, P<0.05). Furthermore, no differences were found in RBP4 levels between lean PCOS women and BMI-matched healthy controls.

Conclusion: In German PCOS women, serum RBP4 levels are associated with obesity and parameters of glucose metabolism but not with PCOS per se.




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