HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Klamer, A Articles by Greisen, G Search for Related Content PubMed PubMed Citation Articles by Klamer, A Articles by Greisen, G

Adiponectin levels measured in dried blood spot samples from neonates born small and appropriate for gestational age

Department of Neonatology (section 5021), National University Hospital, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark, ¹ Department of Clinical Biochemistry, Statens Serum Institut, DK-2300 Copenhagen S, Denmark, ² NANEA at Department of Epidemiology and Social Medicine, Aarhus University, DK-8000 Aarhus C, Denmark and ³ Department of Growth and Reproduction, National University Hospital, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark

(Correspondence should be addressed to A Klamer; Email: anja.klamer{at}rh.dk)

Objective: Adiponectin levels measured in neonatal dried blood spot samples (DBSS) might be affected by both prematurity and being born small for gestational age (SGA). The aim of the study was to measure adiponectin levels in routinely collected neonatal DBSS taken on day 5 (range 3–12) postnatal from infants.

Design: A retrospective case–control study.

Subjects and methods: One hundred and twenty-two infants: 62 very premature (34 SGA) and 60 mature infants (27 SGA). Adiponectin concentrations were determined in stored neonatal DBSS using a sandwich immunoassay based on flow metric Luminex xMap technology.

Results: Adiponectin was measurable in all samples, and repeated measurements correlated significantly (r = 0.94). Adiponectin concentrations were negatively associated with both SGA (B = –0.283, P = 0.04) and prematurity (B = –2.194, P < 0.001), independently of each other. In the premature but not the mature group, adiponectin levels increased with increasing postnatal age at blood sampling (B = 0.175, P < 0.001).

Conclusions: Reliable quantification of adiponectin in stored DBSS is feasible and may be used to study large populations of routinely collected samples. Low levels of adiponectin in neonatal DBSS are associated with SGA as well as prematurity. Blood adiponectin levels increase with postnatal age in premature infants, suggesting a rapid yet unexplained metabolic adaptation to premature extrauterine life.

This article has been cited by other articles:

				S. Mazaki-Tovi, H. Kanety, C. Pariente, R. Hemi, Y. Yinon, A. Wiser, E. Schiff, and E. Sivan Adiponectin and Leptin Concentrations in Dichorionic Twins with Discordant and Concordant Growth J. Clin. Endocrinol. Metab., March 1, 2009; 94(3): 892 - 898. [Abstract] [Full Text] [PDF]