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Diagnostic imaging of dopamine receptors in pituitary adenomas

Departments of Internal Medicine and Nuclear Medicine, ¹ Erasmus MC, Rotterdam, The Netherlands

(Correspondence should be addressed to W W de Herder who is now at the Sector of Endocrinology, Department of Internal Medicine, Erasmus MC, S-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands; Email: w.w.deherder{at}erasmusmc.nl)

This paper was presented at a symposium held at the Erasmus Medical Center, Rotterdam, The Netherlands, 2005. The symposium was jointly organized by LJ Hofland, Erasmus Medical Center, and A Colao, Federico II University of Naples, Italy. Ipsen partially supported the publication of these proceedings.

Abstract

Dopamine D2 receptor scintigraphy of pituitary adenomas is feasible by single-photon emission computed tomography using ¹²³I-S-(–)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-3-iodo-6-methoxybenzamide (¹²³I-IBZM) and ¹²³I-epidepride. ¹²³I-epidepride is generally superior to ¹²³I-IBZM for the visualization of D2 receptors on pituitary macroadenomas. However, ¹²³I-IBZM and ¹²³I-epidepride scintigraphy are generally not useful to predict the response to dopaminergic treatment in pituitary tumour patients. These techniques might allow discrimination of non-functioning pituitary macroadenomas from other non-tumour pathologies in the sellar region. Dopamine D2 receptors on pituitary tumours can also be studied using positron emission tomography with ¹¹C-N-raclopride and ¹¹C-N-methylspiperone.

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