HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Norata, G D Articles by Catapano, A L Search for Related Content PubMed PubMed Citation Articles by Norata, G D Articles by Catapano, A L

Plasma resistin levels correlate with determinants of the metabolic syndrome

¹ Centro SISA per lo Studio della Aterosclerosi, Ospedale Bassini, Cinisello Balsamo, Milano, Italy and ² Department of Pharmacological Sciences, University of Milan, Milano, Italy

(Correspondence should be addressed to G D Norata who is now at Department of Pharmacological Sciences, Via Balzaretti 9, 20100 Milano, Italy; Email: danilo.norata{at}unimi.it)

Objective: The role of resistin in insulin sensitivity and obesity is controversial. Some authors suggest that increased serum resistin levels are associated with obesity, visceral fat, insulin resistance, type 2 diabetes and inflammation, while others failed to observe such correlations. The aim of the present study was to investigate the relationship of plasma resistin levels with markers of the metabolic syndrome and atherosclerosis in a large population-based study.

Design and patients: Plasma resistin levels were determined in 1090 subjects free of any medication selected from the PLIC study (designed to verify the presence of atherosclerotic lesions and progression intima-media thickness (IMT) in the common carotid artery in the general population) and related to the presence of obesity, metabolic syndrome, metabolic abnormalities, cardiovascular risk, and progression of IMT.

Results: Plasma resistin levels were highly positively correlated with triglycerides, waist circumference, waist/hip ratio, systolic blood pressure, and ApoAI/ApoB ratio, while they were inversely correlated with high density lipoprotein and ApoAI levels. This finding was gender specific (mainly in women). Plasma resistin levels were significantly higher in women with the metabolic syndrome compared with controls (4.90 (0.24) ng/ml vs 3.90 (0.11) ng/ml; P<0.01), while no difference was observed in obese subjects. Finally, plasma resistin levels were significantlycorrelated with cardiovascular risk calculated according to the Framingham algorithm (P<0.01).

Conclusion: Plasma resistin levels are increased in presence of the metabolic syndrome and are associated with increased cardiovascular risk.

This article has been cited by other articles:

				H. Forsblad d'Elia, R. Pullerits, H. Carlsten, and M. Bokarewa Resistin in serum is associated with higher levels of IL-1Ra in post-menopausal women with rheumatoid arthritis Rheumatology, July 1, 2008; 47(7): 1082 - 1087. [Abstract] [Full Text] [PDF]

				A. Bakhai Adipokines--targeting a root cause of cardiometabolic risk QJM, June 10, 2008; (2008) hcn066v1. [Abstract] [Full Text] [PDF]

				G. D. Norata, S. Raselli, L. Grigore, K. Garlaschelli, E. Dozio, P. Magni, and A. L. Catapano Leptin:Adiponectin Ratio Is an Independent Predictor of Intima Media Thickness of the Common Carotid Artery Stroke, October 1, 2007; 38(10): 2844 - 2846. [Abstract] [Full Text] [PDF]

				A. A. Ellington, A. R. Malik, G. G. Klee, S. T. Turner, A. D. Rule, T. H. Mosley Jr, and I. J. Kullo Association of Plasma Resistin With Glomerular Filtration Rate and Albuminuria in Hypertensive Adults Hypertension, October 1, 2007; 50(4): 708 - 714. [Abstract] [Full Text] [PDF]