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How to study cancers with a possible intrauterine etiology

Department of Epidemiology, UCLA School of Public Health, University of California, 650 Charles E. Young Drive, Los Angeles, California 90095, USA

(Correspondence should be addressed to J Olsen; Email: jo{at}ucla.edu)

Abstract

The concept that many chronic diseases has an early, even fatal, etiology has inspired funding agencies to support large and long-term follow-up studies starting as early in life as possible. These cohort studies provide new opportunities for studying childhood cancer using data that are less biased than those from case-control studies. However, these studies have to be coordinated to reach sufficient sample sizes and a number of novel ethical concerns have to be solved.