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Transcription factors regulating ß-cell function

Diabetes Discovery Platform, South African Medical Research Council, PO Box 19070, Tygerberg, 7505, South Africa

(Correspondence should be addressed to M E Cerf; Email: marlon.cerf{at}mrc.ac.za)

Abstract

Type 2 diabetes is primarily associated with insulin resistance and ß-cell dysfunction. Maintenance of functional mature ß-cells is imperative for ensuring glucose homeostasis. This can be achieved by optimal expression of key transcription factors that are required for normal pancreatic development and maintaining ß-cell function. Defining the regulation of transcription factors as well as their regulation of important ß-cell genes like insulin will provide further insight into elucidating the mechanisms leading to ß-cell dysfunction.