HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Cerf, M. E Search for Related Content PubMed PubMed Citation Articles by Cerf, M. E

Transcription factors regulating ß-cell function

Diabetes Discovery Platform, South African Medical Research Council, PO Box 19070, Tygerberg, 7505, South Africa

(Correspondence should be addressed to M E Cerf; Email: marlon.cerf{at}mrc.ac.za)

Abstract

Type 2 diabetes is primarily associated with insulin resistance and ß-cell dysfunction. Maintenance of functional mature ß-cells is imperative for ensuring glucose homeostasis. This can be achieved by optimal expression of key transcription factors that are required for normal pancreatic development and maintaining ß-cell function. Defining the regulation of transcription factors as well as their regulation of important ß-cell genes like insulin will provide further insight into elucidating the mechanisms leading to ß-cell dysfunction.

This article has been cited by other articles:

				W. C. Haaland, D. I. Scaduto, M. R. Maldonado, D. L. Mansouri, R. Nalini, D. Iyer, S. Patel, A. Guthikonda, C. S. Hampe, A. Balasubramanyam, et al. A-{beta}- Subtype of Ketosis-Prone Diabetes Is Not Predominantly a Monogenic Diabetic Syndrome Diabetes Care, May 1, 2009; 32(5): 873 - 877. [Abstract] [Full Text] [PDF]

				J. F. Wang and D. J Hill Identification and action of N-myc downstream regulated gene 4 A2 in rat pancreas J. Endocrinol., April 1, 2009; 201(1): 15 - 25. [Abstract] [Full Text] [PDF]

				J. Clements, K. Hens, C. Francis, A. Schellens, and P. Callaerts Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons PNAS, October 21, 2008; 105(42): 16183 - 16188. [Abstract] [Full Text] [PDF]