Eur J Endocrinol
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DOI: 10.1530/eje.1.02088
European Journal of Endocrinology, Vol 154, Issue 2, 175-185
Copyright © 2006 by Society of the European Journal of Endocrinology
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REVIEW

Osteoporosis and male age-related hypogonadism: role of sex steroids on bone (patho)physiology

V Rochira, A Balestrieri, B Madeo, L Zirilli, A R M Granata and C Carani

Chair of Endocrinology, Department of Medicine and Medical Specialties, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy

(Correspondence should be addressed to V Rochira; Email: rochira.vincenzo{at}unimore.it)

Abstract

Male age-related bone loss is caused, at least in part, by hypogonadism that occurs with advancing age. The study of the effects of sex steroids on bone physiology in men has recently highlighted the central role of estrogens on bone pathophysiology. This review focuses on particular aspects of bone physiology and pathophysiology in aging men, noting both the similarities to and the differences from female counterparts. In particular, the role of sex steroids on bone sexual dimorphism in health and disease has been analyzed.




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