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Surgery versus medical follow-up in patients with asymptomatic primary hyperparathyroidism: a decision analysis

¹ Université Paris Descartes, Faculté de Médecine, Services de Santé publique, ² Chirurgie générale et digestive, ³ d’endocrinologie et métabolisme, ⁴ Rhumatologie A, ⁵ Radiologie A and ⁶ Biophysique – médecine nucléaire, AP-HP, groupe hospitalier Cochin – Saint Vincent de Paul, 27 rue du faubourg Saint Jacques, 75014 Paris, France and ⁷ HAS et Service de Santé publique, hôpital Henri Mondor, AP-HP, Université Paris 12, Paris, France

(Correspondence should be addressed to G Vidal-Trécan; Email: gwenaelle.vidal-trecan{at}univ-paris5.fr)

Objectives: To examine the cost-effectiveness of strategies for management of primary asymptomatic hyperparathyroidism: surgical strategies and medical follow-up versus surgery.

Design: We used a Markov state-transition decision-analytic model for an hypothetical cohort of 55-year-old women to compare with a lifetime horizon costs and effectiveness of bilateral neck exploration (BNE), unilateral neck exploration (UNE), video-assisted parathyroidectomy (VAP) and lifelong medical follow-up shifting for either BNE or UNE in case of disease progression.

Methods: Data on localization tests, complications and treatment efficacies were derived from a systematic review of the literature. Outcomes were expressed as quality-adjusted life years (QALY). Costs (2002) discounted at 3% yearly were estimated from the health care system perspective.

Results: In the base-case analysis, VAP strategy (VAPS) was the most effective and BNE strategy (BNES) was the least costly. UNE strategy (UNES) had an incremental cost-effectiveness ratio of 2688/QALY versus BNES and VAPS of 17 250/QALY in comparison with UNES. Surgical management was more effective than medical follow-up with acceptable incremental cost-effectiveness ratios. VAPS became less effective than UNES over 71 years. Differences between UNES and VAPS were sensitive to success and complication rates, quality-of-life weights and procedural costs. Medical follow-up strategies became the most effective if quality-of-life weight for this condition was higher than 0.99.

Conclusions: Surgery is more effective than medical follow-up at a reasonable cost and can be preferred except in patients choosing medical follow-up. Minimally invasive surgery is cost-effective compared to the traditional surgical approach.