| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CLINICAL STUDY |
Department of Pediatrics, 1 Core Unit for Medical Statistics and Informatics and 2 Department of Epidemiology, Cancer Research Institute, Medical University of Vienna, Vienna, Austria
(Correspondence should be addressed to S Riedl, Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18–20, 1090 Vienna, Austria; Email: stefan.riedl{at}meduniwien.ac.at)
Objective: Ghrelin stimulates GH release and causes weight gain through increased food intake and reduced fat utilization. Ghrelin levels were shown to rise in the preprandial period and decrease shortly after meal consumption, suggesting a role as a possible meal initiator. However, ghrelin secretion in fasting subjects has not yet been studied in detail.
Design: 24-h ghrelin profiles were studied in six healthy volunteers (three females; 25.5 years; body mass index 22.8 kg/m2) and compared with GH, insulin and glucose levels.
Methods: Blood samples were taken every 20 min during a 24-h fasting period and total ghrelin levels were measured by RIA using a polyclonal rabbit antibody. The circadian pattern of ghrelin secretion and pulsatility (Cluster analysis) were evaluated.
Results: An increase and spontaneous decrease in ghrelin were seen at the timepoints of customary meals. Ghrelin was secreted in a pulsatile manner with approximately 8 peaks/24 h. An overall decrease in ghrelin levels was observed during the study period. There was no correlation of ghrelin with GH, insulin or blood glucose levels.
Conclusions: This pilot study indicates that fasting ghrelin profiles display a circadian pattern similar to that described in people eating three times per day. In a fasting condition, GH, insulin and glucose do not appear to be involved in ghrelin regulation. In addition, we found that ghrelin is secreted in a pulsatile pattern. The variation in ghrelin independently of meals in fasting subjects supports previous observations that it is the brain that is primarily involved in the regulation of meal initiation.
This article has been cited by other articles:
|
|
 |
|
  R. Nass, L. S. Farhy, J. Liu, C. E. Prudom, M. L. Johnson, P. Veldhuis, S. S. Pezzoli, M. C. Oliveri, B. D. Gaylinn, H. M. Geysen, et al. Evidence for Acyl-Ghrelin Modulation of Growth Hormone Release in the Fed State J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1988 - 1994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, C. E. Prudom, R. Nass, S. S. Pezzoli, M. C. Oliveri, M. L. Johnson, P. Veldhuis, D. A. Gordon, A. D. Howard, D. R. Witcher, et al. Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men J. Clin. Endocrinol. Metab., May 1, 2008; 93(5): 1980 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Frecka and R. D. Mattes Possible entrainment of ghrelin to habitual meal patterns in humans Am J Physiol Gastrointest Liver Physiol, March 1, 2008; 294(3): G699 - G707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J Moran, M. Noakes, P. M Clifton, G. A Wittert, C. W Le Roux, M. A Ghatei, S. R Bloom, and R. J Norman Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1603 - 1610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Anderwald-Stadler, M. Krebs, M. Promintzer, M. Mandl, M. G. Bischof, P. Nowotny, T. Kastenbauer, A. Luger, R. Prager, and C. Anderwald Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1393 - E1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kluge, P. Schussler, M. Uhr, A. Yassouridis, and A. Steiger Ghrelin Suppresses Secretion of Luteinizing Hormone in Humans J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3202 - 3205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Broom, D. J. Stensel, N. C. Bishop, S. F. Burns, and M. Miyashita Exercise-induced suppression of acylated ghrelin in humans J Appl Physiol, June 1, 2007; 102(6): 2165 - 2171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Yannielli, P. C. Molyneux, M. E. Harrington, and D. A. Golombek Ghrelin Effects on the Circadian System of Mice J. Neurosci., March 14, 2007; 27(11): 2890 - 2895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Janovick, S. P. Brothers, P. E. Knollman, and P. M. Conn Specializations of a G-protein-coupled receptor that appear to aid with detection of frequency-modulated signals from its ligand FASEB J, February 1, 2007; 21(2): 384 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. O. Mundinger, D. E. Cummings, and G. J. Taborsky Jr Direct Stimulation of Ghrelin Secretion by Sympathetic Nerves Endocrinology, June 1, 2006; 147(6): 2893 - 2901. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
