Eur J Endocrinol
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DOI: 10.1530/eje.1.01883
European Journal of Endocrinology, Vol 152, Issue 4, 545-550
Copyright © 2005 by European Society of Endocrinology
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CLINICAL STUDY

High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma

Chung-Yau Lo, Kin-Yin Lam1, Pauline P Leung and John M Luk

Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road, Hong Kong China and 1 Discipline of Pathology, School of Medicine, Griffith University, Goldcoast, Australia

(Correspondence should be addressed to Chung Yau Lo; Email: cylo{at}hkucc.hku.hk)

Background: Cyclooxygenase-2 (COX-2) seems to play a role in the development and carcinogenesis of papillary thyroid carcinoma. Its incidence of expression and potential application as a tumor marker remain to be elucidated.

Materials and methods: Immunohistochemical staining for COX-2 expression was performed for 30 papillary thyroid carcinoma (PTC) and 40 benign thyroid specimens. COX-2 mRNA expression was analyzed using a reverse transcriptase-polymerase chain reaction (RT-PCR) for paired fresh frozen tissues removed from surgically resected PTC specimens.

Results: COX-2 expression was detected by immunohistochemistry in 27 of 30 (90%) PTC but was absent in 40 benign thyroid specimens, including 27 nodular hyperplasia, 7 follicular adenoma and 6 lymphocytic thyroiditis. Two of the three COX-2 negative carcinomas were follicular variant of PTC. RT-PCR analysis confirmed COX-2 mRNA over-expression in 14 of 20 (70%) paired specimens of PTC. Real-time quantitative RT-PCR showed that the level of COX-2 mRNA expression was significantly higher in PTC than in both the adjacent non-cancerous tissues and the benign thyroid specimens.

Conclusion: COX-2 is frequently expressed in PTC but not in benign thyroid specimens. COX-2 expression may serve as a useful molecular marker for PTC in cases of diagnostic difficulty.




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