Eur J Endocrinol
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DOI: 10.1530/eje.1.01886
European Journal of Endocrinology, Vol 152, Issue 4, 501-513
Copyright © 2005 by European Society of Endocrinology
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REVIEW

Gonadal dysfunction in systemic diseases

Asterios Karagiannis and Faidon Harsoulis

Second Propedeutic Department of Internal Medicine, Division of Endocrinology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece

(Correspondence should be addressed to A Karagiannis, 44 Tsimiski str., Thessaloniki, 54623, Greece; Email: astkar{at}med.auth.gr)

Abstract

Gonadal function is significantly affected in many acute and chronic systemic diseases. As the function of the testes and the ovaries is determined by the integrity of the hypothalamic–pituitary–gonadal axis, it is obvious that a systemic disease may affect one or more levels of the axis in such a manner that the gonadal dysfunction may have various clinical and laboratory manifestations. In this brief review, the most common disturbances seen in the main systemic diseases will be discussed.




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