Eur J Endocrinol
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DOI: 10.1530/eje.0.1510107
European Journal of Endocrinology, Vol 151, Issue 1, 107-112
Copyright © 2004 by European Society of Endocrinology
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Clinical Studies

High-dose treatment with a long-acting somatostatin analogue in patients with advanced midgut carcinoid tumours

SV Welin, ET Janson, A Sundin, M Stridsberg, E Lavenius, D Granberg, B Skogseid, KE Oberg, and BK Eriksson

Department of Medical Sciences, University Hospital, Uppsala, Sweden.

OBJECTIVE: High-dose somatostatin analogue treatment has shown an antiproliferative effect in one study including patients with neuroendocrine tumours. To explore this therapeutic strategy further, we have studied the effect of a high-dose formula of octreotide, octreotide pamoate, in midgut carcinoid patients. DESIGN AND METHODS: Twelve patients with advanced midgut carcinoid tumours with a median duration of disease of more than 5 years were included. All were in a progressive state despite several previous treatment modalities. Octreotide pamoate (160 mg) was given as an intramuscular injection every 2 weeks for 2 months and then monthly. Radiological and biochemical responses were monitored. RESULTS: Tumour size and biochemical markers were stabilised for a median of 12 months in 75% of the patients. Ten patients had symptomatic improvement of flush and diarrhoea. CONCLUSION: In this group of patients with advanced midgut carcinoid tumours and progressive disease, octreotide pamoate managed to improve symptoms, and stabilise hormone production and tumour growth in 75% of the patients. We believe that high-dose treatment with somatostatin analogues can be an important addition to the therapeutic arsenal for patients with advanced progressive midgut carcinoid tumours.


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