Eur J Endocrinol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

DOI: 10.1530/eje.0.1470571
European Journal of Endocrinology, Vol 147, Issue 5, 571-574
Copyright © 2002 by European Society of Endocrinology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ukkola, O
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ukkola, O
Articles

Resistin - a mediator of obesity-associated insulin resistance or an innocent bystander?

O Ukkola

Department of Internal Medicine and Biocenter Oulu, University of Oulu, Kajaanintie 50/PO Box 5000, FIN-90220 Oulu, Finland. olavi.ukkola@oulu.fi

The objective of this review is to summarize the current evidence of a novel adipocytokine, resistin. Resistin is a novel peptide hormone that belongs to a family of tIssue-specific resistin-like molecules originally named for its resistance to insulin. Although a seminal proposal by Steppan et al. suggested resistin to be a hormone that links obesity to diabetes, several studies have subsequently been published supporting the concept that insulin resistance and obesity are actually associated with a decreased resistin expression. Resistin expression is regulated by a variety of agents and hormones, including thiazolidinediones, insulin, tumor necrosis factor alpha and growth hormone. Studies about their role in the regulation of resistin expression are, however, inconsistent in many cases. Experiments in humans have shown no differences in resistin expression between normal, insulin-resistant or type 2 diabetic samples. However, some recent genetic studies have demonstrated an association between resistin and insulin resistance and obesity. In addition, regional variation in the expression of resistin mRNA and protein levels in humans is an interesting finding with the highest levels found in the abdominal depot. In conclusion, resistin is a fascinating new hormone for which a definite role in metabolism will be revealed in the near future.


This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
G D Norata, M Ongari, K Garlaschelli, S Raselli, L Grigore, and A L Catapano
Plasma resistin levels correlate with determinants of the metabolic syndrome
Eur. J. Endocrinol., February 1, 2007; 156(2): 279 - 284.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
G. E Krassas, N. Pontikides, K. Loustis, G. Koliakos, T. Constantinidis, and D. Panidis
Resistin levels in hyperthyroid patients before and after restoration of thyroid function: relationship with body weight and body composition
Eur. J. Endocrinol., August 1, 2005; 153(2): 217 - 221.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Pagano, O. Marin, A. Calcagno, P. Schiappelli, C. Pilon, G. Milan, M. Bertelli, E. Fanin, G. Andrighetto, G. Federspil, et al.
Increased Serum Resistin in Adults with Prader-Willi Syndrome Is Related to Obesity and Not to Insulin Resistance
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4335 - 4340.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. H. Lee, J. W. Bullen Jr., V. L. Stoyneva, and C. S. Mantzoros
Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia
Am J Physiol Endocrinol Metab, March 1, 2005; 288(3): E625 - E632.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
U. Meier and A. M. Gressner
Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin
Clin. Chem., September 1, 2004; 50(9): 1511 - 1525.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. Nogueiras, M. L. Barreiro, J. E. Caminos, F. Gaytan, J. S. Suominen, V. M. Navarro, F. F. Casanueva, E. Aguilar, J. Toppari, C. Dieguez, et al.
Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors
J. Cell Sci., July 1, 2004; 117(15): 3247 - 3257.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
F. Felipe, M. L. Bonet, J. Ribot, and A. Palou
Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status
Diabetes, April 1, 2004; 53(4): 882 - 889.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. Pfutzner, T. Kunt, C. Hohberg, A. Mondok, S. Pahler, T. Konrad, G. Lubben, and T. Forst
Fasting Intact Proinsulin Is a Highly Specific Predictor of Insulin Resistance in Type 2 Diabetes
Diabetes Care, March 1, 2004; 27(3): 682 - 687.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. H. Lee, J. L. Chan, N. Yiannakouris, M. Kontogianni, E. Estrada, R. Seip, C. Orlova, and C. S. Mantzoros
Circulating Resistin Levels Are Not Associated with Obesity or Insulin Resistance in Humans and Are Not Regulated by Fasting or Leptin Administration: Cross-Sectional and Interventional Studies in Normal, Insulin-Resistant, and Diabetic Subjects
J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 4848 - 4856.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Verma, S.-H. Li, C.-H. Wang, P. W.M. Fedak, R.-K. Li, R. D. Weisel, and D. A.G. Mickle
Resistin Promotes Endothelial Cell Activation: Further Evidence of Adipokine-Endothelial Interaction
Circulation, August 12, 2003; 108(6): 736 - 740.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 European Society of Endocrinology.