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DOI: 10.1530/eje.0.1420623
European Journal of Endocrinology, Vol 142, Issue 6, 623-629
Copyright © 2000 by European Society of Endocrinology
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Articles

Fetal leptin and insulin levels only correlate inlarge-for-gestational age infants

HJ Wolf, CF Ebenbichler, O Huter, J Bodner, M Lechleitner, B Foger, Patsch JR, and G Desoye

Department of Obstetrics and Gynaecology, University of Innsbruck, Austria. hans.wolf@uibk.ac.at

OBJECTIVE: To determine whether fetal leptin levels correlate with fetal weight and whether such correlation is direct or indirect via insulin or human placental lactogen (hPL), respectively. DESIGN: Cross-sectional study of offspring at term (n=175) with over-representation of large-for-gestational age (LGA; n=70) and small-for-gestational age (SGA; n=23) cases in a population of Caucasian women with no pregnancy pathology. METHODS: Fetal cord blood was collected after delivery. In several cases (n=62) paired mother-fetus blood samples were obtained. Leptin, insulin and hPL levels were measured by RIA. Anthropometric data (birth weight, body mass index, placental weight) were recorded. RESULTS AND CONCLUSIONS: Maternal insulin, hPL and leptin levels were higher than fetal concentrations. Cord blood leptin levels positively correlated with the anthropometric data with stronger correlations in female (0.54


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