| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Articles |
Department of Oral Cell Biology, ACTA-Vrije Universiteit, Amsterdam, The Netherlands.
Recently, the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 (also named osteogenic protein-1, OP-1) have been published (1-4). Although both BMPs were able to support bone regeneration, a significant variation in individual response was observed with both proteins. Animal studies and laboratory experiments reveal a number of conditions that influence the osteoinductivity of BMP, such as BMP concentration, carrier properties and influence of local and systemic growth factors and hormones. In this paper, these studies and the clinical reports are reviewed, and the conditions that modulate the BMP-dependent osteoinduction are discussed. The information may provide clues as to how the performance of recombinant human BMP as bone-graft substitute in humans can be improved.
This article has been cited by other articles:
|
|
 |
|
  R. Garimella, S. E. Tague, J. Zhang, F. Belibi, N. Nahar, B. H. Sun, K. Insogna, J. Wang, and H. C. Anderson Expression and Synthesis of Bone Morphogenetic Proteins by Osteoclasts: A Possible Path to Anabolic Bone Remodeling J. Histochem. Cytochem., June 1, 2008; 56(6): 569 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Wang, C. C. Clark, and C. T. Brighton Up-Regulation of Bone Morphogenetic Proteins in Cultured Murine Bone Cells with Use of Specific Electric Fields J. Bone Joint Surg. Am., May 1, 2006; 88(5): 1053 - 1065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tamama, V. H. Fan, L. G. Griffith, H. C. Blair, and A. Wells Epidermal Growth Factor as a Candidate for Ex Vivo Expansion of Bone Marrow-Derived Mesenchymal Stem Cells Stem Cells, March 1, 2006; 24(3): 686 - 695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.T. Franceschi Biological Approaches to Bone Regeneration by Gene Therapy J. Dent. Res., December 1, 2005; 84(12): 1093 - 1103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Hou, K. Adriane, and P. K. Feng Bone in Growth in bFGF Versus BMP Combined with bFGF Saturated PLA-PEG-PLA: Experiment in Surgically Created Rabbit Mandibular Defects Journal of Bioactive and Compatible Polymers, September 1, 2005; 20(5): 455 - 474. [Abstract] [PDF]
|
|
|
|
 |
|
 A. M. Osyczka and P. S. Leboy Bone Morphogenetic Protein Regulation of Early Osteoblast Genes in Human Marrow Stromal Cells Is Mediated by Extracellular Signal-Regulated Kinase and Phosphatidylinositol 3-Kinase Signaling Endocrinology, August 1, 2005; 146(8): 3428 - 3437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.F. Termaat, F.C. Den Boer, F.C. Bakker, P. Patka, and H.J.Th.M. Haarman Bone Morphogenetic Proteins. Development and Clinical Efficacy in the Treatment of Fractures and Bone Defects J. Bone Joint Surg. Am., June 1, 2005; 87(6): 1367 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Cadet, R. I. Gafni, E. F. McCarthy, D. R. McCray, J. D. Bacher, K. M. Barnes, and J. Baron Mechanisms Responsible for Longitudinal Growth of the Cortex: Coalescence of Trabecular Bone into Cortical Bone J. Bone Joint Surg. Am., September 1, 2003; 85(9): 1739 - 1748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Cheng, W. Jiang, F. M. Phillips, R. C. Haydon, Y. Peng, L. Zhou, H. H. Luu, N. An, B. Breyer, P. Vanichakarn, et al. Osteogenic Activity of the Fourteen Types of Human Bone Morphogenetic Proteins (BMPs) J. Bone Joint Surg. Am., August 1, 2003; 85(8): 1544 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Diefenderfer, A. M. Osyczka, J. P. Garino, and P. S. Leboy Regulation of BMP-Induced Transcription in Cultured Human Bone Marrow Stromal Cells J. Bone Joint Surg. Am., August 1, 2003; 85(90003): 19 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Pouliot, A. Blais, and C. Labrie Overexpression of a Dominant Negative Type II Bone Morphogenetic Protein Receptor Inhibits the Growth of Human Breast Cancer Cells Cancer Res., January 15, 2003; 63(2): 277 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kloen, S. B. Doty, E. Gordon, I. F. Rubel, M.-J. Goumans, and D. L. Helfet Expression and Activation of the BMP-Signaling Components in Human Fracture Nonunions J. Bone Joint Surg. Am., November 12, 2002; 84(11): 1909 - 1918. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Theilhaber, T. Connolly, S. Roman-Roman, S. Bushnell, A. Jackson, K. Call, T. Garcia, and R. Baron Finding Genes in the C2C12 Osteogenic Pathway by k-Nearest-Neighbor Classification of Expression Data Genome Res., January 1, 2002; 12(1): 165 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Braddock, P. Houston, C. Campbell, and P. Ashcroft Born Again Bone: Tissue Engineering for Bone Repair Physiology, October 1, 2001; 16(5): 208 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Marcelino, C. M. Sciortino, M. F. Romero, L. M. Ulatowski, R. T. Ballock, A. N. Economides, P. M. Eimon, R. M. Harland, and M. L. Warman Human disease-causing NOG missense mutations: Effects on noggin secretion, dimer formation, and bone morphogenetic protein binding PNAS, September 25, 2001; 98(20): 11353 - 11358. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
