Eur J Endocrinol
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DOI: 10.1530/eje.0.1410625
European Journal of Endocrinology, Vol 141, Issue 6, 625-629
Copyright © 1999 by European Society of Endocrinology
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Dendritic cells produce interleukin-12 in hyperthyroid mice

M Tamura, B Matsuura, S Miyauchi, and M Onji

The Third Department of Internal Medicine, School of Medicine, Ehime University, Ehime, Japan.

We previously reported that serum interleukin-12 (IL-12) levels were significantly increased in patients with hyperthyroid Graves' disease and in normal subjects after administration of thyroid hormone. In the present study, we investigated which cells produce IL-12 and the interactions between IL-12 and thyroid hormones, using a hyperthyroid mouse model. Thyroid hormones induced IL-12 production, and IL-12 was mainly produced by dendritic cells outside the thyroid glands in a hyperthyroid state.


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