Eur J Endocrinol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

DOI: 10.1530/eje.0.1410279
European Journal of Endocrinology, Vol 141, Issue 3, 279-285
Copyright © 1999 by European Society of Endocrinology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vantyghem, M.
Right arrow Articles by Tabarin, A
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vantyghem, M.
Right arrow Articles by Tabarin, A
Case Reports

Aldosterone-producing adenoma without hypertension: a report of two cases

MC Vantyghem, N Ronci, F Provost, A Ghulam, J Lefebvre, X Jeunemaitre, and A Tabarin

Department of Endocrinology, CHRU, 59037 Lille Cedex, France. avantyghem@infonie.fr

Normotensive primary hyperaldosteronism is exceedingly rare. We report two new cases of this syndrome in two middle-aged women, one of Asian origin. The presenting signs were tetany in one case and an adrenal mass in the other. Neither patient had hypertension, despite repeated measurements with a manual armlet. A typical biological profile of primary hyperaldosteronism was demonstrated in both patients, including hypokalemia with inappropriate kaliuresis, elevated resting plasma aldosterone, and undetectable plasma renin activity. The circadian rhythm of blood pressure was studied by ambulatory monitoring pre- and post-operatively. It confirmed the lack of hypertension, but the circadian rhythm of blood pressure was lost before surgery in one patient. Surgical removal of the histologically typical aldosterone-producing adenomas normalized the kalemia. The main finding in these two patients was spontaneously low blood pressure in the post-operative period. This suggests that excess aldosterone induced relative hypertension in these patients whose blood pressure was spontaneously very low. Genetic screening for dexamethasone-sensitive hyperaldosteronism was negative in both patients.


This article has been cited by other articles:


Home page
 HypertensionHome page
L. Mosso, C. Carvajal, A. Gonzalez, A. Barraza, F. Avila, J. Montero, A. Huete, A. Gederlini, and C. E. Fardella
Primary Aldosteronism and Hypertensive Disease
Hypertension, August 1, 2003; 42(2): 161 - 165.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
Y.-F. LIN, S.-H. LIN, W.-S. TSAI, M.R. DAVIDS, and M.L. HALPERIN
Severe hypokalaemia in a Chinese male
QJM, October 1, 2002; 95(10): 695 - 704.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. Mulatero, T. A. Williams, A. Milan, C. Paglieri, F. Rabbia, F. Fallo, and F. Veglio
Blood Pressure in Patients with Primary Aldosteronism Is Influenced by Bradykinin B2 Receptor and {alpha}-Adducin Gene Polymorphisms
J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3337 - 3343.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 European Society of Endocrinology.