| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Studies |
Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands.
OBJECTIVE: Little is known about the association between free IGF-I levels and bone mineral density (BMD). DESIGN: A cross-sectional study of 218 healthy subjects (103 men, 115 women, age 55-80 years) was carried out. METHODS: Fasting serum free IGF-I, total IGF-I, estradiol and sex hormone-binding globulin (SHBG) levels were measured. The ratio of estradiol to SHBG was used as an index of free estradiol. BMD measurements were performed by dual-energy X-ray absorptiometry of the lumbar spine and the proximal femur. RESULTS: In multivariate analyses with BMD of the lumbar spine as the dependent variable and serum free IGF-I, age, body mass index (BMI) and the free estradiol index as independent variables, the free IGF-I was positively related to the BMD of the lumbar spine in men (P = 0.02) but not in women. When the same analyses for the lumbar BMD were performed with total serum IGF-I the association was also only statistically significant in men (P = 0.05). In multivariate analyses with the trochanter BMD as the dependent variable and serum free IGF-I, total IGF-I, age, BMI and the free estradiol index as independent variables, the associations between (free and total) IGF-I and the trochanter BMD in men was of borderline significance. CONCLUSIONS: In elderly men free and total IGF-I were positively related to lumbar BMD, while (free and total) IGF-I was borderline positively related to trochanter BMD. As these relationships were not observed in elderly women, we suggest a weak gender-specific anabolic effect of IGF-I on BMD on trabecular bone.
This article has been cited by other articles:
|
|
 |
|
  A. Frisoli Jr.,, P. H. M. Chaves, M. M. Pinheiro, and V. L. Szejnfeld The Effect of Nandrolone Decanoate on Bone Mineral Density, Muscle Mass, and Hemoglobin Levels in Elderly Women With Osteoporosis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 648 - 653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W. Goderie-Plomp, M. van der Klift, W. de Ronde, A. Hofman, F. H. de Jong, and H. A. P. Pols Endogenous Sex Hormones, Sex Hormone-Binding Globulin, and the Risk of Incident Vertebral Fractures in Elderly Men and Women: The Rotterdam Study J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3261 - 3269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Rivadeneira, J. J. Houwing-Duistermaat, N. Vaessen, J. M. Vergeer-Drop, A. Hofman, H. A. P. Pols, C. M. van Duijn, and A. G. Uitterlinden Association between an Insulin-Like Growth Factor I Gene Promoter Polymorphism and Bone Mineral Density in the Elderly: The Rotterdam Study J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3878 - 3884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Khalil, E. A. Lucas, S. Juma, B. J. Smith, M. E. Payton, and B. H. Arjmandi Soy Protein Supplementation Increases Serum Insulin-Like Growth Factor-I in Young and Old Men but Does Not Affect Markers of Bone Metabolism J. Nutr., September 1, 2002; 132(9): 2605 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M Prelevic Osteoporosis in men J R Soc Med, January 12, 2001; 94(12): 620 - 623. [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Nindl, C. R. Scoville, K. M. Sheehan, C. D. Leone, and R. P. Mello Gender differences in regional body composition and somatotrophic influences of IGF-I and leptin J Appl Physiol, April 1, 2002; 92(4): 1611 - 1618. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
