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Thyroid hormones and energy and fat balance

In the article by Iossa and coworkers, published in this issue (1), the authors studied energy and fat balance in response to an energy dense (i.e. a fat rich) or a low fat diet in hypothyroid rats. The major finding of the study was that eating more fat results in disproportional fat deposition and weight gain in hypothyroidism. This study provides a further aspect of the action of thyroid hormones on energy and macronutrient balance. The data also correspond to the clinical experience of weight gain associated with hypothyroidism. They support the value of a low fat diet.

Overfeeding in healthy man results in a positive energy balance and, thus, weight gain. Surplus fuels during energy surfeit are mainly stored as fat in adipose tissue. One of the important findings that came out of the Vermont study (2) on the effects of long-term overeating was that lean subjects had difficulty

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