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GH deficiency and vascular disease: in search of the linking mechanism

Growth hormone (GH) deficiency is a complex syndrome in which the cardiovascular involvement represents one of the most prominent features. Based on epidemiological evidence, the idea has taken ground that GH deficiency raises the risk of death from cardiovascular disease. A Swedish study by Rosén & Bengtsson (1) in 333 patients with hypopituitarism, treated with multiple replacement therapy except GH, revealed that the mortality rate was twice as high as in age- and sex-matched controls. Interestingly, cerebrovascular disease was among the main causes of death. These findings were largely confirmed by a subsequent German study by Wüster et al. (2) in 122 patients and more recently by another Swedish study by Erfurth et al. (3) in 344 patients. Both studies pointed to an increased prevalence of vascular disease in patients with hypopituitarism treated with conventional therapy.

The hypothesis that panhypopituitary patients have a greater propensity to develop vascular disease received

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				T. B. Twickler, M. J. M. Cramer, G. M. Dallinga-Thie, M. J. Chapman, D. W. Erkelens, and H. P. F. Koppeschaar Adult-Onset Growth Hormone Deficiency: Relation of Postprandial Dyslipidemia to Premature Atherosclerosis J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2479 - 2488. [Full Text] [PDF]