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Non-genomic steroid action—take a closer look, it's not rare! An invited commentary

Not too long ago, one would have been smiled at or at least ignored by peers if claiming a steroid hormone to act rapidly. A steroid hormone had to act slowly through those intracellular receptors that had been discovered as a perfect fit for each particular steroid.

Why should nature provide more sophisiticated means for cellular responses to steroid hormones if a complex mechanism to explain them had already been identified? The dogma of genomic steroid action that involves those intracellular receptors serving as steroiddependent transcription factors certainly had, and still has, its fascinating facets and ruled almost a generation's time of highly successful steroid research. The outstanding achievements of this story, however, confined non-conformist observations for a long time to a place in science that may be described as a fair of honest artifacts at its best, or a state of non-existence at its worst.

Things have changed over