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Pituitary insufficiency and regression of acromegaly caused by pituitary apoplexy following cerebral angiography

Louwerens M, de Herder WW, Postema PTE, Tanghe HLJ, Lamberts SWJ. Pituitary insufficiency and regression of acromegaly caused by pituitary apoplexy following cerebral angiography. Eur J Endocrinol 1996;134:737–40. ISSN 0804–4643

Pituitary apoplexy as a complication of cerebral angiography has been described in only a few case reports. Some studies have reported the clinical resolution of active acromegaly after pituitary apoplexy. We present a patient with active acromegaly due to a growth hormone (GH)-secreting pituitary macroadenoma, who developed anterior and posterior pituitary insufficiency following cerebral angiography. Furthermore, a significant reduction in tumour size was accompanied by normalization of mean 24 h in GH insulin-like growth factor I (IGF-I) and IGF binding protein 3 levels.

WW de Herder, Department of Internal Medicine III and Clinical Endocrinology, University Hospital Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands