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Dichlorodiphenyltrichloroethane and androgen receptor

A recent paper from William Kelce et al. (Nature, 1995; 375:581–585) points out that the major metabolite of dichlorodiphenyltrichloroethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'DDE), is a potent androgen receptor antagonist and can damage male reproduction. According to the authors, DDT and its major metabolite could be one of the factors responsible for the increasing male tract abnormalities reported in humans and animals. Indeed, various recent studies have reported an increased incidence of hypospadias and cryptorchidism and an increased incidence of testicular cancer (1). A recent study has shown that during the past 20 years there has been a decline in the concentration and motility of sperm and in the percentage of normal spermatozoa in fertile men in the Paris region (2). It has been hypothesized that all these changes have a common origin and may be related to environmental exposure or to a change in life style which has