| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Considering the widespread actions of the pineal hormone melatonin in vertebrate organisms, it is remarkable that so few biomedical scientists took the pineal gland seriously until only recently. When melatonin (N-acetyl-5-methoxytryptamine) was discovered in 1958, Lerner and colleagues (1) hoped that it would be a treatment for irregular skin pigmentation that occurs in humans with certain diseases. This action of melatonin in humans has proven unproductive although in non-mammalian vertebrates an association of melatonin with dermal melanophores is well documented (2).
Within a decade of its discovery, melatonin had been shown to be functionally related to neuroendocrine physiology, with the most obvious link being its control of reproductive physiology in photoperiodic rodents (3). By 1972, a scheme defining the role of the pineal gland, seasonally changing photoperiods and annual fluctuations in reproductive competence had been presented (4). These studies were the basis of later tests on the contraceptive potential
This article has been cited by other articles:
|
|
 |
|
  I. IZYKOWSKA, E. GEBAROWSKA, M. CEGIELSKI, M. PODHORSKA-OKOLOW, A. PIOTROWSKA, M. ZABEL, and P. DZIEGIEL Effect of Melatonin on Melanoma Cells Subjected to UVA and UVB Radiation in In Vitro Studies In Vivo, September 1, 2009; 23(5): 733 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kohrle, F. Jakob, B. Contempre, and J. E. Dumont Selenium, the Thyroid, and the Endocrine System Endocr. Rev., December 1, 2005; 26(7): 944 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Mohd. A. Rahman, Y. Azuma, H. Fukunaga, T. Murakami, K. Sugi, H. Fukushi, K. Miura, H. Suzuki, and M. Shirai Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia J. Antimicrob. Chemother., November 1, 2005; 56(5): 861 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Reiter, D.-x. Tan, J. Leon, U. Kilic, and E. Kilic When Melatonin Gets on Your Nerves: Its Beneficial Actions in Experimental Models of Stroke Experimental Biology and Medicine, February 1, 2005; 230(2): 104 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ozguner, G. Aydin, H. Mollaoglu, O. Gokalp, A. Koyu, and G. Cesur Prevention of mobile phone induced skin tissue changes by melatonin in rat: an experimental study Toxicology and Industrial Health, July 1, 2004; 20(6-10): 133 - 139. [Abstract] [PDF]
|
|
|
|
 |
|
 Vijayalaxmi, C. R. Thomas Jr, R. J. Reiter, and T. S. Herman Melatonin: From Basic Research to Cancer Treatment Clinics J. Clin. Oncol., May 15, 2002; 20(10): 2575 - 2601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Oncu, F Gultekin, E Karaoz, I Altuntas, and N Delibas Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidantsy Human and Experimental Toxicology, April 1, 2002; 21(4): 223 - 230. [Abstract] [PDF]
|
|
|
|
|
|
M. Karbownik, R. J. Reiter, S. Burkhardt, E. Gitto, D.-X. Tan, and A. Lewinski Melatonin Attenuates Estradiol-Induced Oxidative Damage to DNA: Relevance for Cancer Prevention Experimental Biology and Medicine, July 1, 2001; 226(7): 707 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bennett, B. McConnell, and M. Fedak Diurnal and seasonal variations in the duration and depth of the longest dives in southern elephant seals (Mirounga leonina): possible physiological and behavioural constraints J. Exp. Biol., January 2, 2001; 204(4): 649 - 662. [Abstract] [PDF]
|
|
|
|
 |
|
 M. I. Pablos, R. J. Reiter, J.-I. Chuang, G. G. Ortiz, J. M. Guerrero, E. Sewerynek, M. T. Agapito, D. Melchiorri, R. Lawrence, and S. M. Deneke Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen J Appl Physiol, August 1, 1997; 83(2): 354 - 358. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
