Eur J Endocrinol
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DOI: 10.1530/eje.0.1340073
European Journal of Endocrinology, Vol 134, Issue 1, 73-76
Copyright © 1996 by European Society of Endocrinology
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Effect of exogenous growth hormone administration on endogenous growth hormone secretion induced by a met-enkephalin analog

Giuseppe Fanciulli, Osvaldo Oliva, Paolo A Tomasi, Alessandra Pala, Alba Bertoncelli, Alessandra Dettori and Giuseppe Delitala

Fanciulli G, Oliva O, Tomasi PA. Pala A. Bertoncelli A, Dettori A, Delitala G. Effect of exogenous growth hormone administration on endogenous growth hormone secretion induced by a met-enkephalin analog. Eur J Endocrinol 1996:134:73–6. ISSN 0804–4643

Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli: in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opioids induce GH secretion in man, we gave the following treatments to six healthy male volunteers: (a) IV saline: (b) a met-enkephalin analog G-DAMME 250 µg IV as a bolus at time ': (c) hGH 2 IU as an IV bolus at time –180'; (d) G-DAMME as above, preceded by hGH as above. In our study. G-DAMME stimulated GH secretion both basally (peak 17.9 ± 6.0 ng/ml) and, to a lesser extent, after hGH pretreatment (6.0 ± 2.7 ng/ml). Since in our study G-DAMME was able to partially overcome the inhibitory effect of hGH administration, it is suggested that opioids act through an inhibition of somatostatin release and not through a GHRH-dependent pathway. However, an additional direct effect of hGH on pituitary somatotrophes cannot be excluded.

Giuseppe Delitala, Chair of Endocrinology, Viale S. Pietro 12, University of Sassari, 07100 Sassari. Italy






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