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¹³¹I treatment of nodular non-toxic goitre

The traditional treatment of a growing nodular non-toxic goitre has for many years been surgical resection or levothyroxine suppressive treatment. During recent years, several studies have reported promising results of ¹³¹I treatment in terms of thyroid size reduction (1–6).

This review outlines the different treatment modalities of non-toxic nodular goitre with special emphasis on ¹³¹I treatment. By the term nodular goitre we include glands with solitary or multiple thyroid nodules with uptake on a scintiscan (hot nodules).

Assessment of goitre size: Goitre is usually defined clinically, as a visible or palpable thyroid gland, and usually WHO grade 0 (absent) to grade III (large goitre) (7) is applied. This is an inaccurate definition, however, mainly due to both large inter- and intraobserver variations. Jarløv et al. (8) found an average error of 39% (range 0–170%) in the clinical assessment of thyroid size compared to ultrasonically determined volume. Therefore, the

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				S. J. Bonnema, F. N. Bennedbak, P. W. Ladenson, and L. Hegedus Management of the Nontoxic Multinodular Goiter: A North American Survey J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 112 - 117. [Abstract] [Full Text] [PDF]