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Effects in skeletal muscle of supraphysiological growth hormone stimulation

Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska Hospital, Göteborg, Sweden: Department of Anatomy and Cell Biology, University of Göteborg, Göteborg, Sweden

The introduction of recombinant growth hormone (GH) has increased the therapeutic use of GH. The most common indication for GH replacement therapy is still the treatment of children with different growth disorders. However, promising studies demonstrating positive effects of GH in GH-deficient adults have been presented and GH treatment of GH-deficient adults is now approved by several European countries (1). This predicts that the number of patients on GH replacement therapy will increase. Unfortunately, parallel with the increased prescription of GH, an increase in the abuse of GH is also suspected. It is still impossible to detect whether an athlete is abusing GH. The reason for this is that recombinant GH has an identical amino acid sequence to the predominant endogenous GH form, the 22-kD

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