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Adrenal androgen production in polycystic ovary syndrome

In the present paper we shall discuss adrenal androgen production in the context of polycystic ovary syndrome (PCOS). It appears to be well established that adrenal androgen production is abnormal in at least some patients with PCOS. Here we will discuss the evidence for abnormalities in adrenal androgen production, explore the underlying mechanisms and address the questions: are disturbances in adrenal androgen production primary or secondary phenomena? and, is there a role for treatment directed towards correction of adrenal androgen abnormalities in the management of PCOS?

The whole area surrounding PCOS and related conditions has been bedeviled by a lack of standardization in the definitions used. For this reason we will begin by defining the terms to be used in this paper and suggest a classification that may help to ensure that the topics under examination in this paper are delineated clearly.

Definitions: Polycystic ovary syndrome (PCOS): Polycystic ovary syndrome