Eur J Endocrinol
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European Journal of Endocrinology, Vol 133, Issue 1, 71-74
Copyright © 1995 by European Society of Endocrinology
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Circadian thyrotropin variations are preserved in normal pregnant women

E Roti, L Bartalena, R Minelli, M Salvi, E Gardini, A Pistolesi, E Martino, and LE Braverman

Centro per lo Studio, Prevenzione, Diagnosi e Cura delle Tireopatie, University of Parma, Italy.

Serum thyrotropin (TSH) concentration circadian rhythm is abolished in many endocrine and non-endocrine diseases. In the present study we have measured serum TSH concentration over 24 h every 2 h in second and third trimester pregnant women. During the 24-h period, serum free thyroxine and free triiodothyronine concentrations did not change significantly. In contrast, serum TSH concentrations demonstrated significant circadian variations both in the second and third trimester pregnant women (p < 0.02 and p < 0.005, respectively). In summary, second and third trimester pregnancy is associated with a normal circadian TSH rhythm.




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Copyright © 1995 European Society of Endocrinology.