HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Menjívar, M. Articles by Pedraza-Chaverri, J. Search for Related Content PubMed Articles by Menjívar, M. Articles by Pedraza-Chaverri, J.

Pituitary–ovarian dysfunction in rats with induced nephrotic syndrome

Menjívar M, Vilchis F, Cárdenas M, Cruz C, Merchant H, Pérez-Palacios G, Pedraza-Chaverri J. Pituitary–ovarian dysfunction in rats with induced nephrotic syndrome. Eur J Endocrinol 1995; 132:502–6. ISSN 0804–4643

The reproductive hormonal profile was evaluated in female rats with experimental nephrotic syndrome induced with a single subcutaneous dose of puromycin aminonucleoside (PAN). Serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (P₄), testosterone and 17β-estradiol (E₂) were determined sequentially in control and experimental groups on days 1,3,7 and 10 after PAN administration. Prolactin levels were also assessed on day 10. In both groups, vaginal smears were taken daily throughout the study to evaluate cyclic histological changes. At the end of the experiment the histological appearance of the ovaries was evaluated by light microscopy. Nephrotic rats had a rapid loss of the estrous cycle starting on day 4, which set them at diestrus. At the same time the hormonal evaluation indicated a gradual decrease in E₂, LH and P₄ concentrations, starting from days 3, 7 and 10, respectively. No significant changes were noted in FSH or testosterone values. Besides, on day 10, prolactin concentrations remained unmodified. Even though most hormonal levels were found low on day 10, all values except E₂ (undetectable) corresponded to the interval reported for the diestrus phase. Likewise, histological examination of ovarian tissue from nephrotic rats showed a considerable increase in the number of atretic follicles. These findings indicate that female rats with nephrotic syndrome develop an important endocrine dysfunction that probably involves steroidogenic tissues (ovary and/or adrenal gland), and suggest the existence of a hypothalamic–hypophyseal impairment.

Marta Menjívar, Department of Reproductive Biology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga N.15, Tlalpan 14000, México, D.F.

This article has been cited by other articles:

				M. Menjívar, M. Cárdenas, G. Ortiz, and J. Pedraza-Chaverrí Fertility Diminution in Female Rats with Experimental Chronic Nephrosis Biol Reprod, November 1, 2000; 63(5): 1549 - 1554. [Abstract] [Full Text]