Eur J Endocrinol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

European Journal of Endocrinology, Vol 131, Issue 6, 623-629
Copyright © 1994 by European Society of Endocrinology
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Misao, R
Right arrow Articles by Tamaya, T
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Misao, R
Right arrow Articles by Tamaya, T
Articles

Sex hormone-binding globulin mRNA levels in human uterine endometrium

R Misao, N Itoh, H Mori, J Fujimoto, and T Tamaya

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.

Sex hormone-binding globulin (SHBG) is a specific steroid hormone-binding protein that plays a role in transporting dihydrotestosterone, testosterone and estradiol-17 beta (E2), altering their concentration in blood and influencing their biological action. Recently it has been reported that immunoreactive SHBG is localized in target tissues and that SHBG mRNA was identified in human endometrial and prostatic cell lines. In the present work, SHBG mRNA was detected in human normal endometrial tissues using Northern blot analysis and polymerase chain reaction. Its level was higher (p < 0.02) in the secretory phase than in the proliferative phase. In the secretory phase, the endometrial SHBG mRNA level was correlated positively with serum E2 and progesterone level (p < 0.05). However, there was a negative correlation between endometrial SHBG mRNA level and serum E2/progesterone ratio (p < 0.01). These findings suggest that SHBG is synthesized in the uterine endometrium and a part of its synthesis is regulated complexly by sex steroid hormones such as E2 and progesterone.


This article has been cited by other articles:


Home page
 EndocrinologyHome page
K.-M. Ng, M.-T. So, and W. M. Lee
Expression of Rabbit Sex Hormone-Binding Globulin during Pregnancy and Prenatal Development and Identification of a Novel Isoform
Endocrinology, April 1, 2005; 146(4): 1965 - 1972.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. K. Rao, C. M. Wayne, M. L. Meistrich, and M. F. Wilkinson
Pem Homeobox Gene Promoter Sequences that Direct Transcription in a Sertoli Cell-Specific, Stage-Specific, and Androgen-Dependent Manner in the Testis in Vivo
Mol. Endocrinol., February 1, 2003; 17(2): 223 - 233.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
W.S. Sun, R. Misao, S. Iwagaki, J. Fujimoto, and T. Tamaya
Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases, Axl and Sky, in human uterine endometrium and ovarian endometriosis
Mol. Hum. Reprod., June 1, 2002; 8(6): 552 - 558.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y.-C. Ip, W. M. Lee, and G. L. Hammond
The Rabbit Sex Hormone-Binding Globulin Gene: Structural Organization and Characterization of Its 5'-Flanking Region
Endocrinology, April 1, 2000; 141(4): 1356 - 1365.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Jänne, H. K. Deol, S. G. A. Power, S.-P. Yee, and G. L. Hammond
Human Sex Hormone-Binding Globulin Gene Expression in Transgenic Mice
Mol. Endocrinol., January 1, 1998; 12(1): 123 - 136.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 European Society of Endocrinology.