Eur J Endocrinol
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European Journal of Endocrinology, Vol 131, Issue 6, 594-597
Copyright © 1994 by European Society of Endocrinology
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Effect of liver damage on the pharmacokinetics of dexamethasone

S Kutemeyer, TH Schurmeyer, and A von zur Muhlen

Abteilung klinische Endokrinologie, Medizinische Hochschule Hannover, Germany.

By measuring the pharmacokinetics of dexamethasone in 48 patients with various degrees of disturbances in liver function, we could demonstrate a decrease in the metabolic clearance of this steroid by 53% if the activity of the plasma cholinesterase was lowered to less than 2 kU/l. Results suggest that the dosage of dexamethasone given for diagnostic or therapeutic purpose needs to be adjusted in such patients.


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N. A. T. M. Huizenga, J. W. Koper, P. de Lange, H. A. P. Pols, R. P. Stolk, D. E. Grobbee, F. H. de Jong, and S. W. J. Lamberts
Interperson Variability but Intraperson Stability of Baseline Plasma Cortisol Concentrations, and Its Relation to Feedback Sensitivity of the Hypothalamo-Pituitary-Adrenal Axis to a Low Dose of Dexamethasone in Elderly Individuals
J. Clin. Endocrinol. Metab., January 1, 1998; 83(1): 47 - 54.
[Abstract] [Full Text]


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