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Influence of interleukin 1 and antihuman interleukin 1 receptor antibody on the growth and function of the thyroid gland in rats

G erek-Mee, K yliska, J Fryczak, S Mucha and H Stpie

erek-Mee G, yliska K, Fryczak J, Mucha S, Stpie H. Influence of interleukin 1 and antihuman interleukin 1 receptor antibody on the growth and function of the thyroid gland in rats. Eur J Endocrinol 1994;131:531–4. ISSN 0804–4643

Cytokines seem to influence the hypothalamo–pituitary–thyroid axis. We have studied the effect of different doses of interleukin 1 (IL-1) and IL-1β (given twice daily ip) alone or together with antihuman IL-1 receptor antibody (aIL-1ra) on the proliferation of thyroid follicular cells and thyroid hormone levels in male Wistar rats. We have examined the influence of IL-1 and IL-1β at doses of 10.0, 1.0 and 0.1 µg/kg body wt of animal and aIL-1ra at a dose of 10.0 µg/kg body wt of animal. The incorporation of bromodeoxyuridine into thyroid follicular cell nuclei was used as an index of cell proliferation (labeling index: LI) and measured 24 h after the last of two injections of interleukin. Interleukin 1β, at all examined doses, increased thyroid follicular cell proliferation when compared to controls (p < 0.05), and a positive correlation between log of the dose of IL-1β used and LI (r = 0.62, p < 0.05) using Student's t-test was found. The administration of aIL-1ra alone also enhanced the thyroid follicular cell proliferation, whereas aIL-1ra used together with IL-1β exerted a less pronounced effect than each of these substances used separately (p < 0.05). Interleukin 1 at the dose of 10.0 µg/kg body wt increased the proliferation of thyroid follicular cells (p < 0.05). Thyroid hormone levels did not change in any of the experiments. These results suggest a regulatory role of IL-1 upon the proliferation of thyroid cells.

Henryk Stpie, Institute of Endocrinology, Medical University of ód, Dr. Sterling Str. 3, 91-425 ód, Poland

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