HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chaouki, M. L Articles by Benmiloud, M. Search for Related Content PubMed Articles by Chaouki, M. L Articles by Benmiloud, M.

Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy

Chaouki ML. Benmiloud M. Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy. Eur J Endocrinol 1994;130:547–51. ISSN 0804–4643

The prevalence of iodine deficiency disorders and the thyroid status of the population were studied in an endemic goitre area in Algeria. After oral administration of lipiodol (0.5 ml), three treated groups of mother–newborn couples were compared to an untreated group: group A, mothers treated 1–3 months before conception; group B, mothers treated during the first month of pregnancy; group C, mothers treated during the third month of pregnancy. Untreated mothers were used as a control (group D). After lipiodol treatment, all newborn babies and mothers were clinically euthyroid. All tested newborn babies were full term and no goitre was observed in the four groups. In the mothers, goitre prevalence and thyrotrophin levels decreased significantly, whereas maternal milk and urinary iodine and serum-free thyroxine levels were significantly higher after treatment. The rate of prematurity, stillbirths and abortions in the treated groups was reduced when compared to the untreated group, whereas placental and birth weights were significantly higher. In group D two cases of neonatal hypothyroidism were detected. Their re-evaluation confirmed that hypothyroidism was transient. Groups A, B and C were statistically different from group D with regard to neonatal thyrotrophin and thyroxine. Positive correlations were found between neonatal thyroxine and birth weights and placental weights on the one hand, and maternal urinary iodine and free thyroxine on the other. Consequently, these data indicate that oral administration of lipiodol before or during the first trimester of pregnancy normalizes thyroid function in newborn babies and mothers, increases placental and birth weight and reduces the frequency of iodine deficiency disorders. Lipiodol at this dose and during the first trimester of pregnancy had no deleterious effects and may prevent hypothyroid or neurological cretinism.

Mohamed Lamine Chaouki, Service d'Endocrinologie, Centre Hospitalo-Universitaire de Batna, Route de Tazoult 05000, Batna, Algeria

This article has been cited by other articles:

				Subsection Reports J. Clin. Endocrinol. Metab., August 1, 2007; 92(8_suppl): s8 - s47. [Full Text] [PDF]

				M. Abalovich, N. Amino, L. A. Barbour, R. H. Cobin, L. J. De Groot, D. Glinoer, S. J. Mandel, and A. Stagnaro-Green Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline J. Clin. Endocrinol. Metab., August 1, 2007; 92(8_suppl): s1 - s47. [Abstract] [Full Text] [PDF]

				M. B. Zimmermann, P. L. Jooste, N. S. Mabapa, X. Mbhenyane, S. Schoeman, R. Biebinger, N. Chaouki, M. Bozo, L. Grimci, and J. Bridson Treatment of Iodine Deficiency in School-Age Children Increases Insulin-Like Growth Factor (IGF)-I and IGF Binding Protein-3 Concentrations and Improves Somatic Growth J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 437 - 442. [Abstract] [Full Text] [PDF]

				C. H.D. Fall, C. S. Yajnik, S. Rao, A. A. Davies, N. Brown, and H. J.W. Farrant Micronutrients and Fetal Growth J. Nutr., May 1, 2003; 133(5): 1747S - 1756. [Abstract] [Full Text] [PDF]

				A. M. d. L. Costello and D. Osrin Micronutrient Status during Pregnancy and Outcomes for Newborn Infants in Developing Countries J. Nutr., May 1, 2003; 133(5): 1757S - 1764. [Abstract] [Full Text] [PDF]

				D. Glinoer The Regulation of Thyroid Function in Pregnancy: Pathways of Endocrine Adaptation from Physiology to Pathology Endocr. Rev., June 1, 1997; 18(3): 404 - 433. [Abstract] [Full Text]

				F. Aghini-Lombardi, L. Antonangeli, A. Pinchera, F. Leoli, T. Rago, A. M. Bartolomei, and P. Vitti Effect of Iodized Salt on Thyroid Volume of Children Living in an Area Previously Characterized by Moderate Iodine Deficiency J. Clin. Endocrinol. Metab., April 1, 1997; 82(4): 1136 - 1139. [Abstract] [Full Text] [PDF]

				C. Cobra, Muhilal, K. Rusmil, D. Rustama, Djatnika, S. S. Suwardi, D. Permaesih, Muherdiyantiningsih, S. Martuti, and R. D. Semba Infant Survival Is Improved by Oral Iodine Supplementation J. Nutr., April 1, 1997; 127(4): 574 - 578. [Abstract] [Full Text]