Eur J Endocrinol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

European Journal of Endocrinology, Vol 130, Issue 5, 508-514
Copyright © 1994 by European Society of Endocrinology
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kissmeyer-Nielsen, P
Right arrow Articles by Laurberg, S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kissmeyer-Nielsen, P
Right arrow Articles by Laurberg, S
Articles

Growth hormone treatment of rats with chronic diverting colostomy. Differential response on proximal functioning and distal atrophic colon

P Kissmeyer-Nielsen, H Christensen, and S Laurberg

Department of Surgery L, Amtssygehuset, University Hospital of Aarhus, Denmark.

Diversion of colon from the fecal stream leads to profound intestinal atrophy. After diverting colostomy for 4 weeks, female rats were treated with biosynthetic human growth hormone (b-hGH; 2.0 mg.kg-1 body wt.day-1) in order to investigate whether b-hGH could reverse atrophic changes in distal colon, with special reference to changes in morphometric composition, collagen content and biomechanical properties. Biosynthetic hGH treatment for 28 days stimulated growth of the muscularis propria of the defunctioned, atrophic colon (p < 0.05), whereas the mucosal atrophy was unaffected by the treatment. In colon proximal to the colostomy, however, b-hGH increased the colonic wet weight (p < 0.01), defatted dry weight (p < 0.005) and the collagen content (p < 0.05). Morphometric analysis showed that the growth increase was localized to the mucosa and the muscularis propria. In conclusion, fecal diversion alters the response of b-hGH treatment and indicates that the trophic effect of growth hormone on colonic mucosa is dependent on fecal bulk passage, whereas the trophic effect on muscularis propria is fully retained when colon is deprived of luminal nutrients.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Ljungmann, B. Hartmann, P. Kissmeyer-Nielsen, A. Flyvbjerg, J. J. Holst, and S. Laurberg
Time-dependent intestinal adaptation and GLP-2 alterations after small bowel resection in rats
Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G779 - G785.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Ljungmann, T. Grofte, P. Kissmeyer-Nielsen, A. Flyvbjerg, H. Vilstrup, N. Tygstrup, and S. Laurberg
GH decreases hepatic amino acid degradation after small bowel resection in rats without enhancing bowel adaptation
Am J Physiol Gastrointest Liver Physiol, October 1, 2000; 279(4): G700 - G706.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 European Society of Endocrinology.