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Decreased chemotaxis of neutrophils in acromegaly and hyperprolactinemia

Cecilia Fornari M, Fernanda Palacios M, Diez RA, Intebi AD. Decreased chemotaxis of neutrophils in acromegaly and hyperprolactinemia, Eur J Endocrinol 1994;130:463–8. ISSN 0804–4643

Both growth hormone (GH) and prolactin (PRL) modulate immune responses in vitro. We studied chemotaxis under agarose of polymorphonuclear cells from patients with acromegaly or hyperprolactinemia. Polymorphonuclear cells were purified by dextran sedimentation and subjected to stimulation with N-formylmethionyl-phenylalanine, The results showed a decrease in both directed migration (acromegaly: 971 ± 155 µm, hyperpolactinemia: 1123 ± 137 µm, expressed as mean± SEM) and spontaneous migration (acromegaly: 270 ± 77 µm: hyperpolactinemia: 298 ± 77 µm) when compared to similar features from normal controls (directed migration: 2019 ± 99 µm: spontaneous migration: 590 ± 49 µm) and from patients with non-GH/PRL-secreting pituitary tumours (directed migration: 1633 ± 282 µm: spontaneous migration: 562 ± 116 µm), suggesting that this defect is selective for acromegaly and hyperprolactinemia. Our results point to a putative direct or indirect effect of GH and PRL on polymorphonuclear cell chemotaxis.

AD Intebi, Endocrinologia, Dpto de Medicina Interna, Hospital "Juan A Fernandez", Cerviño 3356 (125), Buenos Aires, Argentina

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