Eur J Endocrinol
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DOI: 10.1530/eje.0.1300220
European Journal of Endocrinology, Vol 130, Issue 3, 220-223
Copyright © 1994 by European Society of Endocrinology
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Plasma catecholamines after thyrotropin-releasing hormone administration in hypothyroid patients before and during therapy

Antonino Velardo, Graziano Del Rio, Giuseppe Zizzo, Maria G Venneri, Luciano Della Casa and Paolo Marrama

Velardo A, Del Rio G, Zizzo G, Venneri MG, Della Casa L, Marrama P. Plasma catecholamines after thyrotropin-releasing hormone administration in hypothyroid patients before and during therapy. Eur J Endocrinol 1994;130:220–3. ISSN 0804–4643

In order to investigate sympathoadrenal activity in hypothyroidism we studied the cardiovascular and catecholamine responses to thyrotropin-releasing hormone (TRH) infusion in nine hypothyroid patients before and during adequate therapy and in seven healthy subjects. We evaluated mean arterial pressure, heart rate, plasma epinephrine and norepinephrine levels after TRH administration (200 µg iv) in the three groups. Mean arterial pressure, heart rate and plasma epinephrine levels were not different in the three groups and did not change after TRH administration. Hypothyroid subjects showed increased plasma norepinephrine levels (1.48 ± 0.15 nmol/l), which were reduced after euthyroidism was reached (0.84 ± 0.11 nmol/l) (p < 0.01). An exaggerated response of norepinephrine to TRH was observed in hypothyroid patients before therapy (incremental peak (IP) = 0.59 ± 0.13 nmol/l) but not in hypothyroid patients during therapy (IP = 0.19 ± 0.02 nmol/l p < 0.02) or in the control group (IP = 0.15 ± 0.04 nmol/l; p < 0.05). This study indicated that TRH administration is able to influence the sympathetic activity during hypothyroidism in humans.

A Velardo. Cattedra di Endocrinologia, Via del Pozzo 71, 41100 Modena, Italy






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