HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dahl-Jørgensen, K. Articles by Aagenæs, O. Search for Related Content PubMed PubMed Citation Articles by Dahl-Jørgensen, K. Articles by Aagenæs, O.

Reduction of urinary albumin excretion after 4 years of continuous subcutaneous insulin infusion in insulin-dependent diabetes mellitus

Abstract. Urinary albumin was studied in 45 patients with insulin-dependent diabetes in a 4-year prospective randomized trial, comparing continuous SC insulin infusion (CSII), multiple insulin injections, and conventional treatment with twice daily injections. Strict blood glucose control was obtained with CSII and multiple injections, better than with conventional treatment (2P < 0.01): mean glycosylated haemoglobin (% HbA₁±SEM) after 4 years: CSII 9.0 ± 0.4%; multiple injections 9.4 ± 0.4%; conventional treatment 10.5 ± 0.5. A total of 696 24-h urine specimens were collected. After 4 years of CSII from the time of randomization, urinary albumin excretion was reduced (26 ± 5 to 16 ± 4 mg/24 h, mean ± SEM, 2P < 0.01), when compared with conventional treatment (2P=0.01) where no change was observed (21 ± 4 to 22 ± 6 mg/24 h, n.s.). The reduction observed during multiple injection treatment was not significant (17 ± 3 to 14 ± 3 mg/24 h). Long-term nearnormoglycaemia may influence the mechanisms leading to albuminuria in diabetes, if introduced at an early stage of the disease.

This article has been cited by other articles:

				P. Hammond Continuous subcutaneous insulin infusion: short-term benefits apparent, long-term benefits speculative The British Journal of Diabetes & Vascular Disease, March 1, 2004; 4(2): 104 - 108. [Abstract] [PDF]

				L. Poulsen Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes Journal of Renin-Angiotensin-Aldosterone System, December 1, 2002; 3(4): 222 - 242. [Abstract] [PDF]

				P. L. Poulsen, K. W. Hansen, E. Ebbehøj, S. T. Knudsen, and C. E. Mogensen No Deleterious Effects of Tight Blood Glucose Control on 24-Hour Ambulatory Blood Pressure in Normoalbuminuric Insulin-Dependent Diabetes Mellitus Patients J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 155 - 158. [Abstract] [Full Text]

				M. J. Carella, V. V. Gossain, and D. R. Rovner Early Diabetic Nephropathy: Emerging Treatment Options Arch Intern Med, March 28, 1994; 154(6): 625 - 630. [Abstract] [PDF]

				P. Reichard, B.-Y. Nilsson, and U. Rosenqvist The Effect of Long-Term Intensified Insulin Treatment on the Development of Microvascular Complications of Diabetes Mellitus N. Engl. J. Med., July 29, 1993; 329(5): 304 - 309. [Abstract] [Full Text]

				M. Ravid, H. Savin, R. Lang, I. Jutrin, L. Shoshana, and M. Lishner Proteinuria, Renal Impairment, Metabolic Control, and Blood Pressure in Type 2 Diabetes Mellitus: A 14-Year Follow-up Report on 195 Patients Arch Intern Med, June 1, 1992; 152(6): 1225 - 1229. [Abstract] [PDF]

				J. J. Cook and D. Daneman Microalbuminuria in Adolescents With Insulin-Dependent Diabetes Mellitus Arch Pediatr Adolesc Med, February 1, 1990; 144(2): 234 - 237. [Abstract] [PDF]